Select the part of the signature that you want to change, then click the font drop-down box and click a new font. Signature preferences, such as default signatures for new messages and replies, can be managed through the Outlook desktop app. Its in the 'Select signature to edit' box thats in the top-right corner of the Signatures and Stationery window. There are also options to edit previous signatures by selecting said signature and pressing the Edit button and permanently delete signatures by selecting the signature and pressing the minus (-) icon. In the Outlook app, navigate to New Message in the top right corner, click Signature within the panel that will appear upon creating a new message, select Manage Signatures, press the addition (+) sign to add a new signature, name/title the new signature and, after creating it, select the Save icon. In the editing box below the new name, type your signature, then format it with the font, color, and styles to get the appearance you want. Signature preferences, such as default signature, message formatting and default replies, can be handled through the Outlook website. Select New signature, then give it a distinct name. On the Message tab, click Signature, and then click Signatures. Outlook’s main window to create and manage Signatures. Press the New button to create a new signature. When pressing the Signatures button you’ll get an overview of the already configured signatures. Using and logging in with a Microsoft email account, navigate to Settings in the upper left corner, select Compose and reply, press the addition sign (+) icon to add a new signature, name/title the new signature, create it within the box provided and Save it. Under Signature name, click the signature you want to change. To create a signature and set options for it you go to File-> Options-> section Mail-> button Signatures. As full disclosure, I work at Microsoft as a full-ti. Bybrand, a business email signature management firm, released best practices for email signatures in 2023, including what types of fonts to use, adding contact details and more. Learn how to create a signature in Outlook Desktop and Outlook on the web in this step-by-step tutorial.